Titre :
  • Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.
Auteur : Soubhye, Jalal ; Aldib, Iyas ; Elfving, Betina ; Gelbcke, Michel ; Furtmüller, Paul G ; Podrecca, Manuel ; Conotte, Raphaël ; Colet, Jean-Marie ; Rousseau, Alexandre ; Reye, Florence ; Sarakbi, Ahmad ; Vanhaeverbeek, Michel ; Kauffmann, Jean-Michel ; Obinger, Christian ; Neve, Jean ; Prévost, Martine ; Zouaoui Boudjeltia, Karim ; Dufrasne, François ; Van Antwerpen, Pierre
Informations sur la publication : Journal of medicinal chemistry, 56, 10, (page 3943-3958)
Statut de publication : Publié, 2013-05
Sujet CREF : Chimie organique
Mots-clés MeSH : Animals
Carboxylic Acids -- chemistry
Crystallization
Drug Design
Enzyme Inhibitors -- chemical synthesis -- pharmacology -- toxicity
Fluorine -- chemistry
Humans
Indicators and Reagents
Indoles -- chemical synthesis -- chemistry -- pharmacology
Lipoproteins, LDL -- chemistry
Male
Models, Molecular
Nitrogen -- chemistry
Oxidation-Reduction
Peroxidase -- antagonists & inhibitors
Rats
Rats, Wistar
Serotonin Uptake Inhibitors -- chemical synthesis -- pharmacology
Structure-Activity Relationship
Sulfur -- chemistry
Taurine -- analogs & derivatives -- pharmacology
Note : Journal Article
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm4001538
info:pmid/23581551
info:ulb-repo/set/1#29271