par Magedov, Igor V;Lefranc, Florence 
;Frolova, Liliya V;Banuls, Laetitia Moreno Y;Peretti, Amanda S;Rogelj, Snezna;Mathieu, Véronique ;Kiss, Robert ;Kornienko, Alexander
Référence Bioorganic & medicinal chemistry letters, 23, 11, page (3277-3282)
Publication Publié, 2013-06
;Frolova, Liliya V;Banuls, Laetitia Moreno Y;Peretti, Amanda S;Rogelj, Snezna;Mathieu, Véronique ;Kiss, Robert ;Kornienko, AlexanderRéférence Bioorganic & medicinal chemistry letters, 23, 11, page (3277-3282)
Publication Publié, 2013-06
Article révisé par les pairs
| Résumé : | Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses. |
