Titre :
  • Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice.
Auteur : Shinozaki, Shohei ; Inoue, Yoko ; Yang, Wen ; Fukaya, Makiko ; Carter, Edward A ; Yu, Yong-Ming ; Ming-Yu, Young ; Fischman, Alan ; Tompkins, Ronald ; Kaneki, Masao
Informations sur la publication : Biochemical and biophysical research communications, 391, 3, (page 1459-1464)
Statut de publication : Publié, 2010-01
Sujet CREF : undefined
Mots-clés MeSH : Animals
Apoptosis
Disease Models, Animal
Endotoxemia -- drug therapy -- enzymology -- pathology
Enzyme Inhibitors -- therapeutic use
Farnesyltranstransferase -- antagonists & inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use
Lipopolysaccharides
Liver -- drug effects -- enzymology -- pathology
MAP Kinase Kinase 4 -- metabolism
Male
Methionine -- analogs & derivatives -- therapeutic use
Mice
Mice, Inbred C57BL
Simvastatin -- therapeutic use
Spleen -- drug effects -- enzymology -- pathology
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0006-291X 
info:doi/10.1016/j.bbrc.2009.12.094
info:pii/S0006-291X(09)02467-X
info:pmid/20034462
info:pmcid/PMC2813732