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Copper-Mediated Selective Cross-Coupling of 1,1-Dibromo-1-alkenes and Heteronucleophiles: Development of General Routes to Heterosubstituted Alkynes and Alkenes

par Jouvin, Kevin;Coste, Alexis;Bayle, Alexandre;Legrand, Frederic;Karthikeyan, Ganesan;Tadiparthi, Krishnaji;Evano, Gwilherm
Référence Organometallics, 31, page (7933-7947)
Publication Publié, 2012

Article révisé par les pairs

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Résumé :

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing divergent and straightforward entries to numerous building blocks such as bromoenamides, ynamides, ketene N,N-acetals, bromoenol ethers, ynol ethers, ketene O,O-acetals, or vinylphosphonates and further expanding the copper catalysis toolbox with useful and versatile processes.