• Citer

Effect of pectinolytic enzymes on the release of theophylline from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate

par Semde, Rasmané ;Amighi, Karim ;Devleeschouwer, Michel ;Moes, André Jules
Référence International journal of pharmaceutics, 197, page (169-179)
Publication Publié, 2000

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

Theophylline pellets were coated with cellulosic (Aquacoat® ECD 30, Surelease® clear) or acrylic (Eudragit® NE30D, RS30D) polymer aqueous dispersions, containing 10% (related to the insoluble polymer content) of pectin HM or calcium pectinate, using a Uni-Glatt fluidized-bed coating apparatus. When commercial pectinolytic enzymes were added to the dissolution media (0.05 M acetate - phosphate buffer, pH 6.0), the release of theophylline from the coated pellets was generally slower than that observed in the media without enzymes. The enzymatic slowing down of the drug release, depending on the type of the aqueous polymer dispersion used, is more important with mixed Eudragit® NE/calcium pectinate coated pellets. The results obtained have been examined with regard to the validity of the approach based on the combination of pectins and the insoluble polymer aqueous dispersions intended for specific-delivery of drugs to the colon. The mechanism of the hydrophilic drug release from pellets coated with insoluble polymer aqueous dispersions containing an aqueous gel-forming polymer has been also discussed. (C) 2000 Elsevier Science B.V.