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Effect of pluronic acid F-127 on the toxicity towards eukaryotic cells of CSA-13, a cationic steroid analogue of antimicrobial peptides.

par Nagant, Carole ;Savage, P B;Dehaye, Jean-Paul
Référence Journal of applied microbiology, 112, 6, page (1173-1183)
Publication Publié, 2012-06

Article révisé par les pairs

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Résumé :

CSA-13 is an antimicrobial cationic steroid with some toxicity against eukaryotic cells. The purpose of this work was to test whether pluronic acid F-127 could interfere with the toxicity of CSA-13 on human umbilical vein endothelial (HUVEC) without modifying its bactericidal activity against Pseudomonas aeruginosa.