par Block, Sébastien;Stévigny, Caroline 
;De Pauw-Gillet, M. C.;De Hoffmann, E.;Llabrès, G.;Adjakidjé, V.;Quetin-Leclercq, Joëlle
Référence Planta medica, 68, 7, page (647-649)
Publication Publié, 2002
;De Pauw-Gillet, M. C.;De Hoffmann, E.;Llabrès, G.;Adjakidjé, V.;Quetin-Leclercq, JoëlleRéférence Planta medica, 68, 7, page (647-649)
Publication Publié, 2002
Article révisé par les pairs
| Résumé : | The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3β-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 μg/ml) . This is the first report on the cytotoxicity of a trachylobane diterpene. |
