Titre :
  • Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.
Auteur : Migliorini, Domenico ; Bogaerts, Sven ; Defever, Dieter ; Vyas, Rajesh ; Denecker, Geertrui ; Radaelli, Enrico ; Zwolinska, Aleksandra ; Depaepe, Vanessa ; Hochepied, Tino ; Skarnes, William ; Marine, Jean-Christophe
Informations sur la publication : The Journal of clinical investigation, 121, 4, (page 1329-1343)
Statut de publication : Publié, 2011-04
Sujet CREF : Sciences biomédicales
Mots-clés MeSH : Animals
Base Sequence
Cell Proliferation
Female
Heterozygote
Humans
JNK Mitogen-Activated Protein Kinases -- genetics -- metabolism
MAP Kinase Signaling System
Male
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Mutant Strains
Mice, Transgenic
Neoplasms -- etiology -- genetics -- metabolism
Nuclear Proteins -- deficiency -- genetics -- metabolism
Pregnancy
Protein Stability
RNA, Small Interfering -- genetics
Transcription Factor AP-1 -- genetics -- metabolism
Tumor Suppressor Protein p53 -- metabolism
Tumor Suppressor Proteins -- deficiency -- genetics -- metabolism
Ubiquitin-Protein Ligases -- deficiency -- genetics -- metabolism
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9738 
info:doi/10.1172/JCI45784
info:pii/45784
info:pmid/21403399
info:pmcid/PMC3070608