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A prospective randomised evaluation of G-CSF or G-CSF plus oral antibiotics in chemotherapy-treated patients at high risk of developing febrile neutropenia.

par Lalami, Yassine ;Paesmans, Marianne ;Aoun, Michel ;Munoz Bermeo, René Arturo ;Reuss, K;Cherifi, Soraya ;Alexopoulos, Constantinos;Klastersky, Jean
Référence Supportive care in cancer, 12, 10, page (725-730)
Publication Publié, 2004-10

Article révisé par les pairs

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Résumé :

Febrile neutropenia (FN) remains a major dose-limiting complication among patients treated with chemotherapy. Haematopoietic colony stimulating factors (G-CSF and GM-CSF) made possible a significant improvement in the management of FN, both in the therapeutic and in the prophylactic approach. The use of antibiotic prophylaxis also permits a definite reduction of severe infections during neutropenia. Nevertheless, the possible role of these two interventions for secondary prevention of FN is still unclear.