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Abnormalities in the replicative capacity of osteoblastic cells in the proximal femur of patients with osteonecrosis of the femoral head.

par Gangji, Valérie ;Hauzeur, Jean-Philippe;Schoutens, André ;Hinsenkamp, Maurice ;Appelboom, Thierry ;Egrise, Dominique
Référence Journal of rheumatology, 30, 2, page (348-351)
Publication Publié, 2003-02

Article révisé par les pairs

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Résumé :

Aseptic nontraumatic osteonecrosis (ON) of the femoral head is a painful disorder that often leads to femoral head collapse due to subchondral fracture. We postulated that alteration of osteoblast function might play a role in the pathophysiology of ON. We evaluated the ex vivo proliferation rate and differentiation capacity of osteoblasts derived from the intertrochanteric region of the femur and of the iliac crest of patients with ON of the femoral head and compared it with patients with hip osteoarthritis (OA).