par Kolivras, Athanassios 
;De Maubeuge, Josiane;André, Josette ;Song, Micheline
Référence Dermatology, 206, 4, page (381-383)
Publication Publié, 2003
;De Maubeuge, Josiane;André, Josette ;Song, Micheline Référence Dermatology, 206, 4, page (381-383)
Publication Publié, 2003
Article révisé par les pairs
| Résumé : | We report a case of recurrent vulvar ulcerations developed on vegetations associated with Crohn's disease. Lesions responded to low-dose thalidomide treatment. A biopsy revealed a neutrophilic infiltrate with rare giant cells. Vulvar manifestations were consistent with metastatic Crohn's disease or with a reactive neutrophilic dermatitis. Thalidomide reduces the activity of tumor necrosis factor (TNF) alpha by accelerating the degradation of its mRNA. Nowadays, it has become a promising drug in a broad variety of disorders in which TNF-alpha seems to play a pivotal role, including inflammatory bowel diseases. This is the first case report presenting the efficacy of thalidomide in the treatment of vulvar involvement in Crohn's disease. |
