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Robust interlaboratory reproducibility of a gene expression signature measurement consistent with the needs of a new generation of diagnostic tools

par Ach, Robert A.;Floore, Arno;Curry, Bo;Lazar, Vladimir;Glas, Annuska M;Pover, Rob;Tsalenko, Anya;Ripoche, Hugues;Cardoso, Fatima ;d'Assignies, Mahasti Saghatchian;Bruhn, Laurakay;Van't Veer, Laura
Référence BMC genomics, 8, 148
Publication Publié, 2007-06

Article révisé par les pairs

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Résumé :

The increasing use of DNA microarrays in biomedical research, toxicogenomics, pharmaceutical development, and diagnostics has focused attention on the reproducibility and reliability of microarray measurements. While the reproducibility of microarray gene expression measurements has been the subject of several recent reports, there is still a need for systematic investigation into what factors most contribute to variability of measured expression levels observed among different laboratories and different experimenters.