Article révisé par les pairs
| Résumé : | Effect of dioxin and other polychlorinated polyaromatic compounds on mammalian gene's expression is reviewed. The attention is focused on molecular mechanisms of gene promoter activation. We describe first the classical dioxin activation pathway: activation of aryl hydrocarbon receptor (AhR) by dioxin agonists, the association of activated AhR with "Aromatic hydrocarbon receptor nuclear translocator" (Arnt) and the activation by this dimer of the response elements of several genes. We then discuss the interaction of proteins implicated in AhR activation such as hsp90 and Arnt in the cross talk with other cellular regulatory pathways. Action of polychlorinated polyaromatic compounds on genes by mechanisms not involving "dioxin receptor" is also examined. |
