par Gallo, Blanca;Alonso, Rosa M.;Lete, E.;Badia, M.D.;Patriarche, Gaston ;Gelbcke, Michel
Référence Journal of heterocyclic chemistry, 25, 3, page (867-869)
Publication Publié, 1988
Article révisé par les pairs
Résumé : The acid catalyzed hydrolysis of the thienotriazolodiazepine, Brotizolam, 2‐bromo‐4‐(2‐chlorophenyl)‐9‐methyl‐6H‐thieno[3,2‐f][1,2,4]triazolo[4,3‐a][1,4]diazepine (1), has been studied spectrometrically (ir, pmr, cmr, and ms). The cleavage reaction of the azomethine bond is reversible and the open‐ring compound is in equilibrium with the ring closed compound (protonated form of the parent drug). Copyright © 1988 Journal of Heterocyclic Chemistry

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