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Exceptionally high in vitro antitumour activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor, MCF-7, and a colon carcinoma, WiDr

par Gielen, Marcel ;Willem, Rudolph ;Biesemans, Monique;Boualam, Mohammed ;El Khloufi, A;De Vos, Danièle
Référence Applied organometallic chemistry, 6, 3, page (287-291)
Publication Publié, 1992-05

Article révisé par les pairs

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Résumé :

Nine new substituted triphenyltin benzoates of the type Ar3Sn[BOND]OOC[BOND]C6H2XYZ [X = Y = H, Z = 2-OCH3 and 4-F; X = H, Y = 3-F, Z = 5-F; X = H, Y = 2-OH, Z = 5-Cl, 5-NH2, 5-OCH3 and 5-SO3H; X = 2-OH, Y = 3-CH(CH3)2 and Z = 5-CH(CH3)2] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF-7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C.