Titre :
  • Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.
Auteur : Vandurm, Pierre ; Guiguen, Allan ; Cauvin, Christine ; Georges, Benoît ; Le Van, Kiet ; Michaux, Catherine ; Cardona, Christelle ; Mbemba, Gladys ; Mouscadet, Jean-François ; Hevesi, László ; Van Lint, Carine ; Wouters, Johan
Informations sur la publication : European journal of medicinal chemistry, 46, 5, (page 1749-1756)
Statut de publication : Publié, 2011
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Anti-HIV Agents -- chemical synthesis -- chemistry -- pharmacology
Catalytic Domain -- drug effects
Dose-Response Relationship, Drug
Drug Design
HIV -- drug effects
HIV Integrase -- chemistry -- metabolism
HIV Integrase Inhibitors -- chemical synthesis -- chemistry -- pharmacology
Keto Acids -- chemical synthesis -- chemistry -- pharmacology
Models, Molecular
Molecular Structure
Quinolones -- chemical synthesis -- chemistry -- pharmacology
Stereoisomerism
Structure-Activity Relationship
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0223-5234 
info:doi/10.1016/j.ejmech.2011.02.028
info:pii/S0223-5234(11)00139-5
info:pmid/21385662