Titre:
  • Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.
Auteur:Vandurm, Pierre; Guiguen, Allan; Cauvin, Christine; Georges, Benoît; Le Van, Kiet; Michaux, Catherine; Cardona, Christelle; Mbemba, Gladys; Mouscadet, Jean-François; Hevesi, László; Van Lint, Carine; Wouters, Johan
Informations sur la publication:European journal of medicinal chemistry, 46, 5, page (1749-1756)
Statut de publication:Publié, 2011
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Anti-integrase activity
Antiviral activity
Docking
HIV-1 IN
Molecular modeling
Quinolonyl diketo acid
MeSH keywords:Anti-HIV Agents -- chemical synthesis -- chemistry -- pharmacology
Catalytic Domain -- drug effects
Dose-Response Relationship, Drug
Drug Design
HIV -- drug effects
HIV Integrase -- chemistry -- metabolism
HIV Integrase Inhibitors -- chemical synthesis -- chemistry -- pharmacology
Keto Acids -- chemical synthesis -- chemistry -- pharmacology
Models, Molecular
Molecular Structure
Quinolones -- chemical synthesis -- chemistry -- pharmacology
Stereoisomerism
Structure-Activity Relationship
Note générale:Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0223-5234
info:doi/10.1016/j.ejmech.2011.02.028
info:pii/S0223-5234(11)00139-5
info:scp/79953202832
info:pmid/21385662