par Houart, Corinne ;Szpirer, Josiane ;Szpirer, Claude
Référence The International journal of developmental biology, 36, 1, page (109-114)
Publication Publié, 1992-03
Article révisé par les pairs
Résumé : The expression of the alpha-fetoprotein (AFP) gene is developmentally regulated. Active transcription of this gene depends on a proximal enhancer sequence located between positions D-203 bp and -81 bp, upstream the initiation site. This enhancer contains several putative binding sites for transcription factors. By transfection experiments, we showed that the enhancer activity can be driven by interactions with two regulatory factors, namely C/EBP and c-JUN.