par Opdecamp, K;Vanvooren, P.;Riviere, Michèle 
;Arnheiter, H;Motta, R;Szpirer, Josiane ;Szpirer, Claude
Référence Mammalian genome, 9, 8, page (617-621)
Publication Publié, 1998-08
;Arnheiter, H;Motta, R;Szpirer, Josiane ;Szpirer, Claude Référence Mammalian genome, 9, 8, page (617-621)
Publication Publié, 1998-08
Article révisé par les pairs
| Résumé : | The rat gene encoding the microphthalmia-associated transcription factor (Mitf) was assigned to rat Chromosome (Chr) 4q34-q41, as well as the Gata2 and Mem1 genes. Rat Chr 4 is homologous to mouse Chr 6 and human Chr 3, which carry the Mitf (MITF) gene in these species (MMU 6, 40.0 cM, and HSA 3p14.1-p12.3). mib/mib rats, which are characterized by depigmentation, microphtalmy, osteopetrosis, and neurological disorders were shown to bear a deletion covering several kilobases of genomic DNA in the Mitf gene and to lack Mitf mRNA. The Mitf mutation in the mib/mib rats is thus very likely to be a Mitf null mutation, causing a phenotype similar to the one observed in the miVGA-9 mice, but including osteopetrosis as an additional feature. |
