par Fontaine, Véronique 
;Mahieu, M.;Content, Jean
Référence Melanoma research, 8, 1, page (24-30)
Publication Publié, 1998-02
;Mahieu, M.;Content, Jean Référence Melanoma research, 8, 1, page (24-30)
Publication Publié, 1998-02
Article révisé par les pairs
| Résumé : | Interferon regulatory factor-1 (IRF-1) is a cell growth inhibitor, induced by cytokines, which transactivates downstream effector genes. The role of IRF-1 in the antiproliferative effect of interleukin-6 (IL-6) was investigated using the A375 human melanoma cell line. IL-6 is a stronger inhibitor of A375 proliferation compared with interferon-gamma (IFNgamma). However, in contrast to IFNgamma, IL-6 triggered lower IRF-1 DNA binding activity and induced barely detectable IRF-1-dependent transactivation activity. Furthermore, although IFNgamma induces only activation of signal transducer and activator of transcription (STAT) 1, IL-6 activates mainly STAT3. These data suggest that IRF-1 plays a minor role in the antiproliferative effect of IL-6, which uses alternative signalling events to induce growth inhibition in A375 melanoma cells. |
