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Naloxone and alcohol intoxication in the dog

par Lignian, Hervé ;Fontaine, Jeanine ;Askenasi, Robert
Référence Human Toxicology, 2, 2, page (221-225)
Publication Publié, 1983

Article révisé par les pairs

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Résumé :

1 The effects of naloxone upon ethanol-induced coma have been investigated in dogs. In a double blind study, 15 mongrel dogs received ethanol i.v. (4 g/kg) followed by a single dose of naloxone (12 ?g/kg). 2 Naloxone failed to affect either the duration of respiratory arrest or the time to recovery of motor coordination. In similar animals treated with the narcotic analgesic, fentanyl, naloxone induced a dramatic and complete reversal of the narcotic effects within 30 seconds. 3 It is concluded that, if naloxone has any effect in alcoholic coma, it is not comparable with its dramatic action in narcotic coma. © 1984, Sage Publications. All rights reserved.