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Synthesis, characterization, X-ray crystal structure and in vitro antitumour activity of sodium bis[2(3’,6’,9’-trioxadecyl)-1,2-dicarbaclosododecaborane-1-carboxylato]triphenylstannate

par Bregadze, V I;Glazun, S A;Petrovskii, P.V.;Starikova, Z.A.;Buyanovskaya, A.G.;Takazova, R.U.;Gielen, Marcel ;De Vos, Danièle ;Kemmer, Martine;Biesemans, Monique;Willem, Rudolph
Référence Applied organometallic chemistry, 18, 4, page (191-194)
Publication Publié, 2004-04

Article révisé par les pairs

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Résumé :

Sodium bis[2-(3′,6′,9′-trioxadecyl)-1,2-dicarba-closo-dodecaborane-1-carboxylato]triphenylstannate, [(CH3OCH2CH2OCH2CH2OCH2CH2)-1,2-C2B10H10-9-COO)2SnPh3]− Na+, compound 1, was synthesized by the 1:1 condensation of triphenyltin(IV) hydroxide with 2-(3′,6′,9′-trioxadecyl)-1,2-dicarba-closo-dodecaborane-1-carboxylic acid and crystallized in the presence of sodium bicarbonate. Its structure was determined by spectroscopy, elemental analysis and X-ray diffraction. The structure of 1 consists of trigonal bipyramidal [Sn(Ph)3(L)2]− anions and Na+ cations coordinated by oxygen atoms of polyoxaalkyl chains of different stannate anions, forming cation–anion chains elongated along the c axis. Compound 1 is significantly more active in vitro against seven tumour cell lines of human origin than 5-fluorouracil, cis-platin, carboplatin, and previously reported organotin carboranecarboxylates, but is less active than organotin polyoxaalkylcarboxylates. Copyright © 2004 John Wiley & Sons, Ltd.