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Dialkyltin derivatives of dicarboxylic acids: Synthesis, characterization and in vitro antitumor properties

par Gielen, Marcel ;Boualam, Mohammed ;Meriem, Abdelkader ;Mahieu, Bernard;Biesemans, Monique;Willem, Rudolph
Référence Heteroatom chemistry, 3, 4, page (449-452)
Publication Publié, 1992-08

Article révisé par les pairs

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Résumé :

Diorganotin derivatives of dicarboxylic acids, including diethyltin propene-1,3-dicarboxylate, diethyltin homophthalate, and di-n-butyltin tetrafluorophthalate, were tested in vitro against two human tumor cell lines, MCF-7, a mammary tumor, and WiDr, a colon carcinoma. Most of these display lower inhibition doses ID50 than cis-platin. The synthesis and characterization of the last three compounds by Mössbauer spectroscopy, 1H, 13C and/or 119Sn NMR and mass spectrometry, are also presented.