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Structural and conformational characterization of (Z)-17-[2-(triphenylstannyl)vinyl]-4-estren-17β-ol using 2D proton detected 1H[BOND]13C relay and 2D NOESY spectroscopy

par Kayser, François;Biesemans, Monique;Pan, Huade;Gielen, Marcel ;Willem, Rudolph
Référence Magnetic resonance in chemistry, 30, 9, page (877-882)
Publication Publié, 1992-09

Article révisé par les pairs

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Résumé :

Two-dimensional proton detected heteronuclear 1H[BOND]13C relayed coherence transfer, combined with 2D NOESY spectroscopy at 500 MHz, allowed the complete assignment of the 13C and 1H spectra of (Z)-17-[2-(triphenylstannyl)vinyl]-4-estren-17β-ol. The conformation of this compound in solution was established from a 2D NOESY build-up experiment and compared with the solid-state structure obtained from previous x-ray diffraction analysis. Proton–proton coupling constants were obtained from phase-sensitive 1H double quantum filtered COSY spectroscopy.