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Biomodulation du facteur de transcription NF-κB par les radiations ionisantes

par Magne, Nicolas;Didelot, Céline ;Toillon, Robert-Alain ;Van Houtte, Paul ;Peyron, Jean François
Référence Cancer radiothérapie, 8, 5, page (315-321)
Publication Publié, 2004-10

Article révisé par les pairs

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Résumé :

NF-κB (Nuclear Factor -κB) was described for the first time in 1986 as a nuclear protein binding to the kappa immunoglobulin-light chain enhancer. Since then, NF-κB has emerged as an ubiquitous factor involved in the regulation of numerous important processes as diverse as immune and inflammatory responses, apoptosis and cell proliferation. These last two properties explain the implication of NF-κB in the tumorigenic process as well as the promise of a targeted therapeutic intervention. This review focuses on the current knowledge on NF-κB regulation and discusses the therapeutic potential of targeting NF-κB in cancer in particular during radiotherapy. © 2004 Elsevier SAS. Tous droits réservés.