par Waelbroeck, Magali ;Camus, Jean Claude ;Tastenoy, Michèle ;Christophe, Jean
Référence FEBS letters, 226, 2, page (287-290)
Publication Publié, 1988-01
Référence FEBS letters, 226, 2, page (287-290)
Publication Publié, 1988-01
Article révisé par les pairs
Résumé : | The NB-OK 1 human neuroblastoma cell line expressed muscarinic cholinergic receptors that could be labeled with N-[3H]methylscopolamine (a nonselective antagonist). 80% of these receptors showed high affinity for pirenzepine, i.e. belonged to the M 1 subtype found in neuronal tissues. Their binding properties were identical to those of rat hippocampus M 1 receptors, and differed from those of rat pancreas and heart muscarinic receptors. The remaining (20%) muscarinic receptors showed low affinity for pirenzepine and AF-DX 116, being therefore of an M2 beta (or B) subtype, and were similar to rat pancreatic receptors. |