par Goole, Jonathan 
;Vanderbist, Francis ;Amighi, Karim
Référence International journal of pharmaceutics, 334, 1-2, page (35-41)
Publication Publié, 2007-04
;Vanderbist, Francis ;Amighi, Karim Référence International journal of pharmaceutics, 334, 1-2, page (35-41)
Publication Publié, 2007-04
Article révisé par les pairs
| Résumé : | This work relates to the development and the in vitro evaluation of sustained-release minitablets (MT), prepared by melt granulation and subsequent compression, which are designed to float over an extended period of time. Levodopa was used as a model drug. The importance of the composition and manufacturing parameters of the MT on their floating and dissolution properties was then examined. The investigation showed that MT composition and MT diameter had the greatest influence on drug release, which was sustained for more than 8 h. By using the same formulation, the best floating properties were obtained with 3 mm MT prepared at low compression forces ranging between 50 and 100 N. Their resultant-weight (RW) values were always higher than those obtained with a marketed HBS dosage form within 13 h. When they were filled into gelatin capsules, no sticking was observed. By evaluating the dissolution profiles of levodopa at different pH values, it was found that dissolution profiles depend more on the prolonged-release ability of Methocel® K15M than on the pH-dependent solubility of levodopa. Finally, the robustness of the floating MT was assessed by testing the drug release variability in function of the stirring conditions during dissolution tests. © 2006 Elsevier B.V. All rights reserved. |
