par Mahieu, Brigitte;Souery, Daniel 
;Lipp, Olivier;Mendelbaum, Karine ;Verheyen, Geert R.;De Maertelaer, Viviane ;Van Broeckhoven, Christine;Mendlewicz, Julien
Référence Psychiatry research, 70, 2, page (65-69)
Publication Publié, 1997-05
;Lipp, Olivier;Mendelbaum, Karine ;Verheyen, Geert R.;De Maertelaer, Viviane ;Van Broeckhoven, Christine;Mendlewicz, Julien Référence Psychiatry research, 70, 2, page (65-69)
Publication Publié, 1997-05
Article révisé par les pairs
| Résumé : | The serotonergic system is implicated in the pathogenesis of affective disorders. In particular, the role of the postsynaptic 5-hydroxytryptamine (serotonin) type 2 receptor (5-HT2) has been documented by several studies. The 5-HT2A receptor gene located on chromosome 13 (13q14-21) can be considered a candidate gene for bipolar affective disorder (BPAD). We tested association between a 5-HT2A receptor DNA variant and BPAD using a case- control design. Eighty-three BPAD patients and 129 unrelated normal controls, carefully matched for sex and geographical origin, were studied. Allele and genotype frequencies as well as homo-heterozygote distribution at the 5-HT2A receptor polymorphism were compared between the two groups. No significant allelic or genotypic associations were observed. There was no significant difference for homo-heterozygote distribution between the two groups. These preliminary results may indicate that in our sample the 5-HT2 receptor polymorphism studied is unlikely to play a role in the genetic susceptibility to BPAD. |
