par Vachiery, Jean-Luc ;Reuse, Charles;Blecic, Serge ;Contempre, Bernard ;Vincent, Jean Louis
Référence The American journal of emergency medicine, 8, 6, page (492-495)
Publication Publié, 1990
Article révisé par les pairs
Résumé : Bretylium tosylate has been shown effective in the treatment of ventricular fibrillation and in the prevention of its recurrence. However, lidocaine is generally preferred because bretylium could have adverse hemodynamic effects related to its antiadrenergic action. To explore further the differences between these two antiarrhythmic agents, the authors compared the effects of bretylium, lidocaine, and saline on a standardized dog model of ventricular fibrillation followed by electromechanical dissociation (EMD). The protocol included three successive episodes of cardiac arrest in each animal. Three minutes before each episode of ventricular fibrillation, 5 mg/kg of bretylium tosylate (n = 11), 1 mg/kg of lidocaine (n = 9) or saline (n = 12) were administered blindly. There was no difference in the duration of cardiac arrest (bretylium, 8 min 18 sec; lidocaine, 7 min 54 sec; saline, 8 min 20 sec) or the total doses of epinephrine required to resuscitate the animals. Both bretylium and lidocaine appeared to preserve cardiac function 5 minutes after recovery, as stroke volume increased from 17.8 ± 6.7 to 18.7 ± 6.7 mL (NS) after bretylium and from 17.7 ± 7.7 to 19.0 ± 7.0 mL (NS) after lidocaine, but decreased from 19.0 ± 5.3 to 14.6 ± 6.0 mL (P < .05) after saline. During the first 10 minutes of EMD, ventricular fibrillation or ventricular tachycardia recurred in 4 dogs treated with lidocaine, 3 dogs treated with saline, but no dog treated with bretylium (P < .05 between bretylium and saline). On this dog model of cardiac arrest, bretylium had no adverse effect on hemodynamic recovery and was more effective than lidocaine in preventing the early recurrence of malignant ventricular arrhythmias. Nevertheless, there was no clear superiority of one agent over the other, and the protective effects of either agent were very limited.