par Vincent, Jean Louis 
;De Backer, Daniel
Référence Acta anaesthesiologica Scandinavica. Supplementum, 39, 107, page (229-237)
Publication Publié, 1995
;De Backer, Daniel Référence Acta anaesthesiologica Scandinavica. Supplementum, 39, 107, page (229-237)
Publication Publié, 1995
Article révisé par les pairs
| Résumé : | More than a decade ago, observations of co‐variance between VO2 and DO2 led to the identification of a condition known as pathological O2 supply dependency. This condition was subsequently observed in critically ill patients with sepsis and acute circulatory failure. More recently, other authors have challenged the existence of this condition, often citing methodological problems or mathematical coupling to account for spurious observations in the earlier studies. Here, we review the evidence for and against pathological O2 supply dependency. We find that many of the arguments have some validity but only in specific circumstances. We conclude, therefore, that pathological O2 supply dependency is a hallmark of acute circulatory failure and that an effective therapeutic approach should be based on an evaluation of organ system function in each individual case. Parameters such as blood lactate, pHi and veno‐arterial Pco2 may be useful in this respect. Copyright © 1995 Acta Anaesthesiol Scand |
