Article révisé par les pairs
Résumé : OF1 Swiss male and female mice received adriamycin (ADM) i.p. in increasing doses. Animals were killed after 2 or 4 days. Hearts were removed and mitochondria were isolated. ADM induced an inactivation of the respiratory enzymes closely related to an increase of the mitochondrial membrane viscosity and of the lipid peroxidation. Two ADM derivatives studied similarly did not produce these effects.