par Praet, Michel;Laghmiche, M;Pollakis, Georges 
;Goormaghtigh, Erik ;Ruysschaert, Jean Marie
Référence Biochemical pharmacology, 35, 17, page (2923-2928)
Publication Publié, 1986-09
;Goormaghtigh, Erik ;Ruysschaert, Jean Marie Référence Biochemical pharmacology, 35, 17, page (2923-2928)
Publication Publié, 1986-09
Article révisé par les pairs
| Résumé : | Mice received 4' Epi-adriamycin (4' Epi-ADM) i.p. in increasing doses. After 48 hours, hearts were removed and mitochondria were isolated. 4' Epi-ADM had no effect on the enzymatic activities of complexes I-III and complex IV of the mitochondrial respiratory chain; no modification of the mitochondrial membrane viscosity was observed and only a slight membrane lipid peroxidation was measured. On the contrary, in vitro studies showed a 4' Epi-ADM dependent enzymatic inactivation of complex I-III and IV, correlated with a mitochondrial membrane rigidification and an enhanced lipid peroxidation rate. |
