par Malaisse, Willy 
;Sener, Abdullah
Référence Biochemical pharmacology, 30, 10, page (1039-1041)
Publication Publié, 1981
;Sener, Abdullah Référence Biochemical pharmacology, 30, 10, page (1039-1041)
Publication Publié, 1981
Article révisé par les pairs
| Résumé : | The effects of nifedipine and four chemically related drugs upon insulin release by isolated rat islets were compared. All drugs inhibited glucose-induced insulin release. The dose-action relationship yielded comparable slopes, each ten-fold increase in drug concentration causing a 42.1 ± 1.1 per cent fall in insulin output. However, the ED50 for the inhibitory effects of the drug ranged from 0.99.10-8 M (Bay k 5552) to 0.84.10-7 M (Bay a 1040). Total suppression of glucose-stimulated insulin release was invariably seen at a 10-6 M concentration of each drug. It is concluded that, despite significant variation in its potency, a calcium-antagonistic property is shared by nifedipine and several structurally related compounds. |
