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Predictions of Protein-Protein Interactions at the Atomic Scale

par Wodak, Shoshana ;Mendez Giraldez, Raul ;Lensink, Marc
Référence Supramolecular Structure and Function, Vol. 9, page (1-20)
Publication Publié, 2007

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Résumé :

The use of computational procedures to predict protein-protein interactions from sequence and structure information has attracted renewed interest in recent years with the realization that such procedures can fruitfully complement and guide experimental characterizations of these interactions. CAPRI (Critical Assessment of Predicted Interactions) the community-wide experiment for assessing blind predictions of protein complexes is playing an important role in fostering progress in protein docking algorithms-the computational procedures for predicting the 3D structure of a protein complex from those of the individual components. In this paper we provide our view of the major challenges that docking algorithms must meet. We then describe how current docking methods address these challenges by presenting a summary of results obtained in rounds 1-5 of the CAPRI experiment, and discuss the lessons learned from these results. © 2007 Springer Science+Business Media B.V.