Gene expression model (in)validation by Fourier analysis.

Konopka, Tomasz; Rooman, Marianne

doi:doi/10.1186/1752-0509-4-123

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Gene expression model (in)validation by Fourier analysis.

par Konopka, Tomasz

;Rooman, Marianne

Référence B M C Systems Biology, 4, page (123)
Publication Publié, 2010

Article révisé par les pairs

Résumé :

The determination of the right model structure describing a gene regulation network and the identification of its parameters are major goals in systems biology. The task is often hampered by the lack of relevant experimental data with sufficiently low noise level, but the subset of genes whose concentration levels exhibit an oscillatory behavior in time can readily be analyzed on the basis of their Fourier spectrum, known to turn complex signals into few relatively noise-free parameters. Such genes therefore offer opportunities of understanding gene regulation quantitatively.

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