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Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid.

par Van Antwerpen, Pierre ;Dufrasne, François ;Lequeux, Mathieu;Zouaoui Boudjeltia, Karim ;Lessgyer, I.;Babar, Sajida ;Moreau, Patrick ;Moguilevsky, Nicole ;Vanhaeverbeek, Michel ;Ducobu, Jean ;Neve, Jean
Référence European journal of pharmacology, 570, 1-3, page (235-243)
Publication Publié, 2007-09

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Titre:	Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid.
Auteur:	Van Antwerpen, Pierre; Dufrasne, François; Lequeux, Mathieu; Zouaoui Boudjeltia, Karim; Lessgyer, I.; Babar, Sajida; Moreau, Patrick; Moguilevsky, Nicole; Vanhaeverbeek, Michel; Ducobu, Jean; Neve, Jean
Informations sur la publication:	European journal of pharmacology, 570, 1-3, page (235-243)
Statut de publication:	Publié, 2007-09
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Chronic inflammatory syndromes
	Compound II
	Flufenamic acid
	Human myeloperoxidase
	LDL
	Non-steroidal anti-inflammatory drugs
MeSH keywords:	Anti-Inflammatory Agents, Non-Steroidal -- metabolism
	Cell Line
	Chlorine -- metabolism
	Cholesterol, LDL -- metabolism
	Endothelial Cells -- metabolism
	Flufenamic Acid -- metabolism
	Humans
	Hydrogen Peroxide -- metabolism
	Hypochlorous Acid -- metabolism
	Oxidation-Reduction
	Peroxidase -- antagonists & inhibitors
	Peroxidase -- metabolism
	Recombinant Proteins -- metabolism
Note générale:	Journal Article
Langue:	Anglais
Identificateurs:	urn:issn:0014-2999
	info:doi/10.1016/j.ejphar.2007.05.057
	info:pii/S0014-2999(07)00658-9
	info:scp/34547837573
	info:pmid/17610876