par Malaisse, Willy 
;Devis, Ghislain;Herchuelz, André ;Sener, Abdullah ;Somers, G
Référence Diabète & métabolisme, 2, 1, page (1-4)
Publication Publié, 1976-03
;Devis, Ghislain;Herchuelz, André ;Sener, Abdullah ;Somers, GRéférence Diabète & métabolisme, 2, 1, page (1-4)
Publication Publié, 1976-03
Article révisé par les pairs
| Résumé : | Mg2+ in high concentration (10 to 20 mEq/l) caused a dose-related inhibition of glucose-induced 45calcium net uptake and subsequent insulin release in isolated islets. Experiments performed with the isolated perfused pancreas indicated that the inhibitory effect of Mg2+ upon insulin secretion was rapid and reversible. Although excess Mg2+ reduced lactate production by the islets, the process of glucose recognition by the B-cell was apparently unaltered as judged by the inhibitory effect of the hexose upon 45calcium efflux from perifused islets and the resultant accumulation of 45calcium in the islets. Mg2+ in high concentration failed to facilitate 45calcium efflux from the islets, whether in the presence or absence of glucose. These data suggest that the major effect of Mg2+ upon islet function is to inhibit Ca2+ entry in the B-cell. |
