Titre :
  • 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships.
Auteur : Pirotte, B ; Podona, T ; Diouf, O ; de Tullio, Pascal ; Lebrun, Philippe ; Dupont, L ; Somers, Fabian ; Delarge, Jacques ; Morain, P ; Lestage, P ; Lepagnol, J ; Spedding, Michael
Informations sur la publication : Journal of medicinal chemistry, 41, 16, (page 2946-2959)
Statut de publication : Publié, 1998-07
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adenosine Triphosphate -- metabolism
Allosteric Regulation
Animals
Benzothiadiazines -- chemistry
Benzothiadiazines -- pharmacology
Cerebral Cortex -- metabolism
Cyclic S-Oxides -- chemical synthesis
Cyclic S-Oxides -- chemistry
Cyclic S-Oxides -- pharmacology
Diazoxide -- chemistry
Diazoxide -- pharmacology
Drug Design
Excitatory Postsynaptic Potentials -- drug effects
Hippocampus -- drug effects
Hippocampus -- metabolism
Hippocampus -- physiology
Insulin -- secretion
Insulin Antagonists -- chemical synthesis
Insulin Antagonists -- chemistry
Insulin Antagonists -- pharmacology
Islets of Langerhans -- drug effects
Islets of Langerhans -- metabolism
Islets of Langerhans -- secretion
Male
Mice
Mice, Inbred DBA
Oocytes -- drug effects
Oocytes -- metabolism
Potassium Channels -- drug effects
RNA, Messenger -- biosynthesis
Rats
Rats, Wistar
Receptors, AMPA -- biosynthesis
Receptors, AMPA -- drug effects
Receptors, AMPA -- genetics
Solubility
Stereoisomerism
Structure-Activity Relationship
Thiadiazines -- chemical synthesis
Thiadiazines -- chemistry
Thiadiazines -- pharmacology
Xenopus laevis
Note : In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm970694v
info:pii/jm970694v
info:pmid/9685234