Titre :
  • Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
Auteur : de Tullio, Pascal ; Becker, Bénédicte ; Boverie, Stéphane ; Dabrowski, Michael ; Wahl, Philip ; Antoine, Marie-Hélène ; Somers, Fabian ; Sebille, Sophie ; Ouedraogo, Raogo ; Hansen, John Bondo ; Lebrun, Philippe ; Pirotte, Bernard
Informations sur la publication : Journal of medicinal chemistry, 46, 15, (page 3342-3353)
Statut de publication : Publié, 2003-07
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adenosine Triphosphate -- metabolism
Animals
Aorta -- drug effects
Aorta -- physiology
Benzothiadiazines
Diazoxide -- analogs & derivatives
Diazoxide -- chemical synthesis
Diazoxide -- chemistry
Diazoxide -- pharmacology
Female
Glucose -- pharmacology
Insulin -- secretion
Ion Channel Gating
Islets of Langerhans -- drug effects
Islets of Langerhans -- metabolism
Islets of Langerhans -- secretion
Isomerism
Molecular Conformation
Muscle Relaxation -- drug effects
Muscle, Smooth, Vascular -- drug effects
Muscle, Smooth, Vascular -- physiology
Oocytes -- drug effects
Oocytes -- physiology
Organ Specificity
Patch-Clamp Techniques
Potassium Channels -- drug effects
Rats
Rats, Wistar
Structure-Activity Relationship
Xenopus laevis
Note : In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm021117w
info:pmid/12852765