Titre :
  • Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.
Auteur : Khelili, Smail ; Lebrun, Philippe ; de Tullio, Pascal ; Pirotte, Bernard
Informations sur la publication : Bioorganic & medicinal chemistry, 14, 10, (page 3530-3534)
Statut de publication : Publié, 2006-05
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Contractile activity
Cromakalim derivatives
Insulin secretion
Potassium channel openers
Mots-clés MeSH : Animals
Aorta -- drug effects
Benzopyrans -- chemistry
Benzopyrans -- pharmacology
Cromakalim -- analogs & derivatives
Cromakalim -- chemistry
Cromakalim -- pharmacology
Drug Evaluation, Preclinical
Female
Hypoglycemic Agents -- pharmacology
Insulin -- biosynthesis
Islets of Langerhans -- drug effects
Molecular Structure
Rats
Structure-Activity Relationship
Urea -- analogs & derivatives
Urea -- chemistry
Urea -- pharmacology
Uterine Contraction -- drug effects
Vasodilation -- drug effects
Vasodilator Agents -- chemistry
Vasodilator Agents -- pharmacology
Note : In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0968-0896 
info:doi/10.1016/j.bmc.2006.01.009
info:pii/S0968-0896(06)00044-7
info:pmid/16455262