Titre :
  • Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
Auteur : Khelili, Smail ; Florence, Xavier ; Bouhadja, Mourad ; Abdelaziz, Samia ; Mechouch, Nadia ; Mohamed, Yekhlef ; de Tullio, Pascal ; Lebrun, Philippe ; Pirotte, Bernard
Informations sur la publication : Bioorganic & medicinal chemistry, 16, 11, (page 6124-6130)
Statut de publication : Publié, 2008-06
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Inhibition of insulin secretion
Potassium channel opener
Ring-opened cromakalim analogues
Vasorelaxant effect
Mots-clés MeSH : Animals
Aorta -- drug effects
Aorta -- metabolism
Benzopyrans -- chemical synthesis
Benzopyrans -- chemistry
Benzopyrans -- pharmacology
Chromans -- chemical synthesis
Chromans -- chemistry
Chromans -- pharmacology
Cromakalim -- analogs & derivatives
Cromakalim -- pharmacology
Insulin -- secretion
Insulin Antagonists -- chemical synthesis
Insulin Antagonists -- pharmacology
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- metabolism
Insulin-Secreting Cells -- secretion
Muscle Relaxation -- drug effects
Potassium Channels -- metabolism
Rats
Rats, Wistar
Note : In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0968-0896 
info:doi/10.1016/j.bmc.2008.04.043
info:pii/S0968-0896(08)00375-1
info:pmid/18479927