Titre:
  • Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
Auteur:Pirotte, Bernard; de Tullio, Pascal; Nguyen, Quynh Anh; Somers, Fabian; Fraikin, Pierre; Florence, Xavier; Wahl, Philip; Hansen, John Bondo; Lebrun, Philippe
Informations sur la publication:Journal of medicinal chemistry, 53, 1, page (147-154)
Statut de publication:Publié, 2010-01
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Adenosine Triphosphate -- metabolism
Animals
Benzothiadiazines -- chemical synthesis
Benzothiadiazines -- chemistry
Benzothiadiazines -- pharmacology
Cell Line
Chlorine -- chemistry
Cyclic S-Oxides -- chemical synthesis
Cyclic S-Oxides -- chemistry
Cyclic S-Oxides -- pharmacology
Diazoxide -- analogs & derivatives
Diazoxide -- chemistry
Diazoxide -- pharmacology
Drug Evaluation, Preclinical
Glucose -- pharmacology
Humans
Insulin -- secretion
Islets of Langerhans -- drug effects
Islets of Langerhans -- secretion
Molecular Structure
Muscle, Smooth, Vascular -- drug effects
Muscle, Smooth, Vascular -- metabolism
Potassium Channels -- drug effects
Potassium Channels -- metabolism
Rats
Stereoisomerism
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0022-2623
info:doi/10.1021/jm9010093
info:pmid/19919106