Titre :
  • Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.
Auteur : Gillotin, Florian ; Chiap, Patrice ; Frédérich, Michel ; Van Heugen, Jean-Claude ; Francotte, Pierre ; Lebrun, Philippe ; Pirotte, Bernard ; de Tullio, Pascal
Informations sur la publication : Drug metabolism and disposition, 38, 2, (page 232-240)
Statut de publication : Publié, 2010-02
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : ATP-Binding Cassette Transporters -- metabolism
Animals
Benzothiadiazines -- metabolism
Chromatography, High Pressure Liquid -- methods
Cyclic S-Oxides -- metabolism
Diazoxide -- analogs & derivatives
Diazoxide -- metabolism
Humans
Ion Channel Gating -- drug effects
Isomerism
KATP Channels -- metabolism
Magnetic Resonance Spectroscopy -- methods
Male
Membrane Transport Modulators -- metabolism
Metabolic Detoxication, Phase I
Microsomes, Liver -- metabolism
Phenobarbital -- pharmacology
Potassium Channels, Inwardly Rectifying -- metabolism
Protein Isoforms -- antagonists & inhibitors
Protein Isoforms -- metabolism
Rats
Rats, Sprague-Dawley
Receptors, Drug -- metabolism
Solid Phase Extraction -- methods
Tandem Mass Spectrometry -- methods
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0090-9556 
info:doi/10.1124/dmd.109.028928
info:pii/dmd.109.028928
info:pmid/19875500