Titre :
  • New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
Auteur : Sebille, Sophie ; de Tullio, Pascal ; Florence, Xavier ; Becker, Bénédicte ; Antoine, Marie-Hélène ; Michaux, Catherine ; Wouters, Johan ; Pirotte, Bernard ; Lebrun, Philippe
Informations sur la publication : Bioorganic & medicinal chemistry, 16, 10, (page 5704-5719)
Statut de publication : Publié, 2008-05
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Benzopyrans
Cromakalim analogues
KATP channels
Potassium channel openers
Mots-clés MeSH : ATP-Binding Cassette Transporters -- drug effects
Animals
Aorta -- cytology
Aorta -- drug effects
Benzopyrans -- chemistry
Benzopyrans -- pharmacology
Cromakalim -- chemistry
Cromakalim -- pharmacology
Diazoxide -- analogs & derivatives
Diazoxide -- chemistry
Diazoxide -- pharmacology
Drug Evaluation, Preclinical
Insulin-Secreting Cells -- cytology
Insulin-Secreting Cells -- drug effects
Molecular Structure
Pinacidil -- chemistry
Pinacidil -- pharmacology
Potassium Channels -- drug effects
Quantum Theory
Rats
Rats, Wistar
Stereoisomerism
Structure-Activity Relationship
Temperature
Time Factors
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0968-0896 
info:doi/10.1016/j.bmc.2008.03.065
info:pii/S0968-0896(08)00302-7
info:pmid/18406154