Regulation and quality control by Lon-dependent proteolysis.

Van Melderen, Laurence; Aertsen, Abram

doi:doi/10.1016/j.resmic.2009.08.021

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Regulation and quality control by Lon-dependent proteolysis.

par Van Melderen, Laurence

;Aertsen, Abram
Référence Research in microbiology, 160, 9, page (645-651)
Publication Publié, 2009-11

Article révisé par les pairs

Résumé :

After their first discovery in Escherichia coli, Lon homologues were found to be widely distributed among prokaryotes to eukaryotes. The ATP-dependent Lon protease belongs to the AAA(+) (ATPases associated with a variety of cellular activities) superfamily, and is involved in both general quality control by degrading abnormal proteins and in the specific control of several regulatory proteins. As such, this enzyme has a pivotal role in quality control and cellular physiology. This review focuses on mechanisms of degradation both from the protease and substrate points of view, and discusses the role of Lon in global regulation, stress response and virulence.

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