par Seutin, Vincent;Verbanck, Paul ;Massotte, Laurent;Dresse, Alain
Référence European journal of pharmacology, 164, 2, page (373-376)
Publication Publié, 1989-05
Article révisé par les pairs
Résumé : A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging from 20 to 100% at 10(-7) M. Experiments performed in low-Ca2+, high-Mg2+ medium also showed a significant inhibition by galanin (10(-7) M) in three out of five neurons, which suggests that the peptide acts directly.