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Current concepts: I. The 24-hour profile of prolactin in depression.

par Mendlewicz, Julien ;Van Cauter, Eve ;Linkowski, Paul ;L'Hermite, Marc ;Robyn, Claude
Référence Life sciences, 27, 22, page (2015-2024)
Publication Publié, 1980-12

Article révisé par les pairs

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Résumé :

The 24-hour profile of plasma PRL was studied in 10 patients with unipolar depression and 8 patients with bipolar depression and compared to 18 control profiles obtained in healthy subjects. Alterations in the basal PRL secretion as well as the characteristics of the 24-hour rhythm were found in all patients but differed strikingly according to the type of depressive illness. The basal PRL level was elevated in unipolars, mainly as a result of increased secretion during wakefulness, and lowered in bipolars because of a lack or reduction of sleep-associated elevation. The nocturnal rise of PRL was maintained in unipolars but absent in 75% of the bipolar subjects. The variability of PRL levels around the 24-hour mean appeared to be reduced in both types of affective illness. These abnormalities in the 24-hour profile of PRL could serve as a biological marker of sub-types of depression. © 1980.