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CCK nerve terminals in the rat striatal and limbic areas originate partly in the brain stem and partly in telencephalic structures.

par Gilles, Christian;Lotstra, Françoise ;Vanderhaeghen, Jean-Jacques
Référence Life sciences, 32, 15, page (1683-1690)
Publication Publié, 1983-04

Article révisé par les pairs

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Résumé :

After direct injection of colchicine into the rat rostral caudateputamen, levels of cholecystokinin-like immunoreactive (CCK-IR) material in this part of the nucleus are significantly lowered, and CCK-IR neuronal cell bodies are not demonstrable in the caudateputamen, although numerous ones are revealed in some adjacent telencephalic regions. Direct injection of kainic acid into the rostral caudate-putamen is not followed by a decrease of CCK-IR material in the lesioned region. Twenty one days after injection of 6-hydroxydopamine into the rat ventral mesencephalon, a significant decrease of CCK-IR material is observed in the frontal pole, the pyriform cortex, the nucleus accumbens and the ventral mesencephalon itself, but not in the caudate-putamen. After brain stem hemitransection, no decrease in CCK-IR material is observed in the rostral caudate-putamen.