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Enhancement of memory in cannabinoid CB1 receptor knock-out mice.

par Reibaud, M;Obinu, M C;Ledent, Catherine ;Parmentier, Marc ;Böhme, Georg Andrees;Imperato, Assunta
Référence European journal of pharmacology, 379, 1, page (R1-R2)
Publication Publié, 1999-08

Article révisé par les pairs

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Résumé :

We have used cannabinoid CB knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. These results suggest that endogenous cannabinoid CB receptors play a crucial role in the process of memory storage and retrieval.