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Control of thyroid cell proliferation and goitrogenesis.

par Dumont, Jacques Emile ;Maenhaut, Carine ;Lamy, Florimond
Référence Trends in endocrinology and metabolism, 3, 1, page (12-17)
Publication Publié, 1992

Article révisé par les pairs

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Résumé :

Human thyroid cells proliferate during development and in adults in response to physiologic and pathologic stimuli. Under normal conditions, they turn over about once every 8 years. The main physiologic regulators are thyrotropin and iodide and, in disease, thyroid-stimulating and thyroid-blocking antibodies. Growth factors modulate proliferation in vitro, but their role in vivo is still unknown. Mitogenic effects are mediated via three major pathways: the cyclic AMP, protein tyrosine kinase, and the Ca(2+) phosphatidylinositol cascades. In this review, the role of these cascades in hyperthyroidism, congenital thyroid defects, and autonomous adenoma is analyzed.