Titre:
  • Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas.
Auteur:Parma, Jasmine; Duprez, Laurence; Van Sande, Jacqueline; Cochaux, Pascale; Gervy Decoster, Christine; Mockel, Jean; Dumont, Jacques; Vassart, Gilbert
Informations sur la publication:Nature (London), 365, 6447, page (649-651)
Statut de publication:Publié, 1993-10
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Adenoma -- genetics
Adenoma -- metabolism
Adenoma -- physiopathology
Adenylate Cyclase -- metabolism
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cyclic AMP -- metabolism
DNA Mutational Analysis
DNA Primers
DNA, Neoplasm
Enzyme Activation
Forskolin -- pharmacology
GTP-Binding Proteins -- metabolism
Humans
Hyperthyroidism -- genetics
Hyperthyroidism -- metabolism
Inositol Phosphates -- metabolism
Molecular Sequence Data
Mutation
Protein Conformation
Receptors, Thyrotropin -- genetics
Thyroid Neoplasms -- genetics
Thyroid Neoplasms -- metabolism
Thyroid Neoplasms -- physiopathology
Thyrotropin -- pharmacology
Transfection
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0028-0836
info:doi/10.1038/365649a0
info:scp/0027369421
info:pmid/8413627